SINCE The second world war, medical science has progressed with a stage where competitive medications are for sale to treat the identical ailment in several people. This isn’t just about brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall glance at the various factors that decide your selection of a certain drug.
Safety: The subsequent sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug even if they have certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but have the potential side-effect of addiction.
* Long-term safety: drug could possibly be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and several chemicals react to make a different chemical, which has an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects on a single or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This causes more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same effect on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicine is more intense.
Tolerability: A medication could possibly be effective although not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability need to be considered. Efficacy: A medication isn’t equally effective in all patients. As an example, some patients with depression or anxiety attacks experience relief from escitalopram, but there are lots of who don’t, who therefore need to be prescribed a different anti-depressant. The pace of start of therapeutic action is a vital the answer to be considered too.
Cost: Cost does not necessarily mean the cost of purchase of a specific medicine alone. It ought to also cover the cost of treatments for a complication which could arise while using a different drug. Example: In a individual who insists on taking alcohol and yet should be treated for depression is normally administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (for example tricyclics) may cause a whole new condition in such patients, which would demand a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in these patients.
Simple treatment: The best mode of administration is preferred. If you find an alternative between an injection and oral administration, aforementioned is preferred if your efficacy of the two modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to make a decision simple treatment.
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