SINCE Wwii, medical science has progressed to a stage where competitive medications are around for treat the identical ailment in several people. This is not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall go through the various factors that decide picking a a certain drug.
Safety: These sub-criteria should be considered underneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug even when it’s got certain side-effects as long as the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the possibility side-effect of addiction.
* Long-term safety: medicine could possibly be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and several chemicals reply to develop a different chemical, which has an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This will cause more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same relation to the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the two medicine is more serious.
Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability need to be taken into account. Efficacy: A drug isn’t equally great at all patients. For example, some patients with depression or panic attacks experience relief from escitalopram, but there are many who don’t, who therefore need to be prescribed an alternative anti-depressant. The rate of onset of therapeutic action is a vital the answer to be considered too.
Cost: Cost does not always mean the price of buying a certain medicine alone. It should also cover the price of management of a complication which could arise by using an alternative drug. Example: Within a one who insists on taking alcohol yet has to be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (like tricyclics) may cause a brand new problem in such patients, which could require a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram instead of a cheaper tricyclic such patients.
Simplicity of treatment: The best mode of administration is preferred. If you have an alternative between a shot and oral administration, aforementioned is preferred in the event the efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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