Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. As a result, SARMs bring about anabolic cellular activity while avoiding many of the negative effects of currently available given. SARMs happen to be studied inside the treatments for breast cancer and cachexia and also have recently been used as performance-enhancing agents. Here, we evaluate and summarize the existing literature on SARMs.
Aim
To provide the setting, mechanisms, current and potential clinical applications, and also risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and lean body mass. Both basic research and scientific studies were included.
Main Outcome Measure
To complete overview of peer-reviewed literature.
Results
Though there are currently no U.S. Drug and food Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Preliminary research has devoted to the pharmacokinetics and pharmacodynamics of those agents, demonstrating good availability using a paucity of drug interactions. Early clinical studies have demonstrated potential uses of SARMs in the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good success.
Conclusion
SARMs have several possible clinical applications, with promise for that safe used in treating cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
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