SINCE Wwii, medical science has progressed into a stage where competitive medications are around for treat the identical ailment in numerous people. It’s not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall consider the various factors that decide the selection of a specific drug.
Safety: The subsequent sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even though they have certain side-effects provided that the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the potential side-effect of addiction.
* Long-term safety: medicine directory could be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals react to produce a different chemical, that have an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This causes more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same impact on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the prescription medication is more serious.
Tolerability: A drug could be effective however, not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability need to be taken into account. Efficacy: A drug is not equally good at all patients. As an example, some patients with depression or panic disorders experience rest from escitalopram, but there are lots of who don’t, who therefore need to be prescribed an alternative anti-depressant. The pace of onset of therapeutic action is a factor to be looked at too.
Cost: Cost does not always mean the expense of buying a certain medicine alone. It must also cover the expense of treatment of a complication that could arise by using an alternative drug. Example: In a individual that insists on taking alcohol but must be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another group of anti-depressants (like tricyclics) might cause a fresh problem in such patients, which would have to have a different and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The best mode of administration is preferred. If you find a choice between a shot and oral administration, rogues is preferred if the efficacy of both the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to decide simple treatment.
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