SINCE Wwii, medical science has progressed into a stage where competitive medications are around to treat the identical ailment in various people. This is simply not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall consider the various factors that decide the selection of a certain drug.
Safety: The next sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug even when it’s certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the possibility side-effect of addiction.
* Long-term safety: medicine directory may be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals answer make a different chemical, which has an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for the metabolism. This will cause an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same influence on the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both medicine is more serious.
Tolerability: A medicine may be effective and not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability have to be taken into consideration. Efficacy: A medicine is not equally efficient at all patients. For instance, some patients with depression or panic disorders experience respite from escitalopram, but there are several that don’t, who therefore have to be prescribed a different anti-depressant. The rate of onset of therapeutic action is a crucial factor to be regarded as too.
Cost: Cost does not mean the price of acquiring a specific medicine alone. It should also cover the price of treatment of a complication that will arise from utilizing a different drug. Example: In the individual that insists on taking alcohol but must be treated for depression is usually administered an SSRI drug as these drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (including tricyclics) could cause a brand new problem in such patients, which would need a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in such patients.
Simple treatment: The simplest mode of administration is preferred. If you have a choice between a shot and oral administration, aforementioned is preferred if your efficacy of both modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to decide simple treatment.
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