SINCE The second world war, medical science has progressed with a stage where competitive medications are for sale to treat the same ailment in different people. This is simply not almost brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall go through the various factors that decide your selection of a certain drug.
Safety: The following sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug even if it’s certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: medicationdirectory.com could possibly be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals respond to make a different chemical, that have an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of each other, have certain effects on a single or maybe more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This makes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually make the same relation to the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both prescription medication is more serious.
Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability must be taken into consideration. Efficacy: A drug isn’t equally good at all patients. By way of example, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several that do not, who therefore must be prescribed a different anti-depressant. The pace of start of therapeutic action is a vital factor to be regarded as too.
Cost: Cost doesn’t imply the price tag on acquiring a particular medicine alone. It should also cover the price tag on treatments for a complication which could arise while using a different drug. Example: In a individual who insists on taking alcohol yet must be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the effects of alcohol, whereas another band of anti-depressants (like tricyclics) could cause a new problem in such patients, which could demand a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simple treatment: The best mode of administration is preferred. If you find an option between an injection and oral administration, aforementioned is preferred when the efficacy of both modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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