SINCE World War II, medical science has progressed with a stage where competitive medications are for sale to treat precisely the same ailment in various people. This isn’t just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall glance at the various factors that decide selecting a certain drug.
Safety: The following sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even when it has certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the possibility side-effect of addiction.
* Long-term safety: directory could be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals react to develop a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of the other, have certain effects using one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon due to the metabolism. This will cause an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually produce the same impact on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two prescription medication is more serious.
Tolerability: A drug could be effective however, not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A drug isn’t equally effective in all patients. For example, some patients with depression or anxiety disorders experience relief from escitalopram, but there are several that don’t, who therefore need to be prescribed a different anti-depressant. The interest rate of onset of therapeutic action is a the answer to be regarded too.
Cost: Cost doesn’t imply the price of buying some medicine alone. It will also cover the price of management of a complication that will arise from using a different drug. Example: Within a one who insists on taking alcohol but should be treated for depression is usually administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (such as tricyclics) can cause a fresh condition in such patients, which may need a different and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.
Simplicity of treatment: The easiest mode of administration is preferred. When there is a choice between an injection and oral administration, rogues is preferred when the efficacy of the two modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to decide simple treatment.
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