SINCE World War II, medical science has progressed with a stage where competitive medications are available to treat precisely the same ailment in different people. It’s not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall go through the various factors that decide selecting a selected drug.
Safety: The next sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even when it has certain side-effects provided that the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: http://medicationdirectory.com could be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals reply to make a different chemical, which has an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects one or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This makes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually produce the same influence on precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both drugs are more intense.
Tolerability: A medication could be effective and not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability need to be considered. Efficacy: A medication is not equally effective in all patients. As an example, some patients with depression or anxiety attacks experience relief from escitalopram, but there are several who don’t, who therefore need to be prescribed some other anti-depressant. The interest rate of beginning of therapeutic action is an important factor to be considered too.
Cost: Cost does not always mean the price tag on acquiring a specific medicine alone. It ought to also cover the price tag on treatments for a complication that could arise by using some other drug. Example: Within a person who insists on taking alcohol yet needs to be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (for example tricyclics) might cause a brand new overuse injury in such patients, which could require a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram as opposed to a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If you have a choice between a shot and oral administration, aforementioned is preferred if the efficacy of both modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key point to determine simplicity of treatment.
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